Drug testing reagents

SAFETY reagent

Most of the chemicals that make up these reagents are highly toxic and corrosive. Use of gloves and eye protection is recommended!

Concentrated sulfuric acid is present in almost all of the reagents and represents a large percentage of the total content.

Concentrated H2SO4 causes severe chemical burns to tissue such as eyes and skin. May cause severe internal burns if ingested. Use extreme care when working with the reagents.

In case of contact:

Eyes: Immediately flush eyes and skin with copious amounts ofwater for atleast 15 minutes, holding lids apart to ensure flushingof theentire surface. Do NOT allow victim to rub eyesor keep eyes closed. Get medical aid immediately.

Skin: Get medical aidimmediately. Immediately flushskin withcopious quantities ofsoapand water for at least 15 minutes whileremoving contaminated clothingand shoes. SPEEDY ACTION ISCRITICAL! Call a physician.

Ingestion: Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Consult aphysician immediately. Never give anything by mouth to an unconscious person.

Inhalation: Get medical aid immediately. Remove patient from exposure to fresh air immediately. Administer approved oxygen supply ifbreathing is difficult. Administer artificial respiration or CPR if breathing has ceased. Call a physician.

MARQUIS reagent

One of the most versatile and usually a first choice. Able to distinguish between MDMA, (meth) amphetamine, 2C-B, 2C-I, bk-MDMA, NM-2AI and many many others.

Marquis reagent is made from 98 % sulphuric acid, formaldehyde and methanol. (100 mL of concentrated (95–98%) sulfuric acid to 5 mL of 40% formaldehyde)

When fresh, marquis reagent is a transparent liquid. After a while it slowly start to turn brown. Generally it should be useful for atleast some time after turning brown.

MANDELIN reagent

Mandelin is specifically useful for distinguishing ketamine and PMA.

Mandelin reagent is made from concentrated sulphuric acid and ammonium metavanadate. (100 mL of concentrated (95–98%) sulfuric acid to 1 g of ammonium vanadate)

When fresh, mandelin is a yellow green color and starts to turn green with age. It is also very sensitive to air so keep all of your containers tight shut.

Mecke reagent

Specially useful for identification of opioids.

Mecke reagent is composed from concentrated sulphuric acid and selenious acid. (100 mL of concentrated (95–98%) sulfuric acid to 1 g of selenious acid)

When fresh, mecke is a transparent liquid.

H2so4 reagent

Concentrated sulphuric acid alone can be used for some substances.

When fresh H2SO4 is a transparent liquid.

Ehrlich's reagent

Used to identify indoles, mainly tryptamines and ergoloids.

Ehrlich's reagent is composed of p–dimethylaminobenzaldehyde (DMAB), ethanol and concentrated HCl. (0.5-2.0 g of p–dimethylaminobenzaldehyde (DMAB) in 50 mL of 95% ethanol and 50 mL of concentrated hydrochloric acid)

Cobalt thiocyanate reagent

Used to test for presence of cocaine. The cobalt thiocyanate reagent can be prepared by dissolving ten grams of cobalt (II) thiocyanate in a mixture of 490 milliliters of distilled water and 500 milliliters of glycerin.

Liebermann reagent

Used to test for cocaine, PMA, PMMA, but is also very useful in identification of synthetic cannabinoids.

Liebermann reagent is composed of potasium nitrite and concentrated sulphuric acid. (1g of potassium nitrite for every 10 mls of sulphuric acid)

Froehde reagent

Used to test for opioids but produces diverse color reactions with many substances.

It is composed of molybdate and concentrated sulphuric acid.(100 mL of hot, concentrated (95–98%) sulfuric acid to 0.5 g of molybdate)

Simon's reagent

Reacts with secondary amines such as MDMA and methamphetamine. It is usually used after marquis or mandelin to help differentiate between substances (methamphetamine/amphetamine and MDMA/MDA).

Simon's reagent is composed of a mixture of sodium nitroprusside, sodium carbonate and acetaldehyde.

Solution A: Dissolve 1 g of sodium nitroprusside in 50 mL of distilled water and add 2 mL of acetaldehyde to the solution with thorough mixing. Solution B: 2 percent sodium carbonate in distilled water.

Procedure: Add 1 volume of solution A to the drug, followed by 2 volumes of solution B.

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